Axoclamp 900A microelectrode amplifier

The Axoclamp 900A is the newest microelectrode amplifier from Molecular Devices. Like the Axoclamp-2B amplifier, Axoclamp 900A offers several modes of operation that measure signals from single cells, tissue slices, and whole animal preparations. The advanced signal conditioning included in the Axoclamp 900A amplifier saves the expense of buying additional hardware and frees up valuable space in an electrophysiology setup. By making Axoclamp 900A computer-controlled, several powerful new features have been added to make it simpler to set up and run experiments. This exciting new instrument is designed to meet researchers’ needs today, as well as offer fl exibility for future experiments.

SEVERAL MODES OF OPERATION

This versatile amplifier offers several modes of operation. Current clamp (I-Clamp), for measuring voltage responses, is available in two channels with independent Bridge Balance and I=0 options. Discontinuous current clamp (DCC) is especially useful when small changes in electrode resistance occur during an experiment. Two-electrode voltage clamp (TEVC) uses two microelectrodes, one for continuous recording of electrode voltage and the other for injection of current. The high-output compliance of TEVC makes it possible to voltage clamp large rapid currents. Discontinuous single-electrode voltage clamp (dSEVC) is used to voltage clamp small cells that cannot tolerate impalement by a second electrode and eliminates problems due to the large series resistance inherent with many preparations. High voltage current clamp (HVIC) is used primarily for extra cellular iontophoresis applications